Semantic web integration of gene structure and protein structure information

Most mammalian genes have more than one splice form. Alternative splicing can yield a variety of protein products from a single gene, with the proteins differing in amino acid sequence, domain composition, and subcellular localization. This talk illustrates how semantic web technologies can integrate information on protein structure, splice variation, and tissue expression, revealing knowledge on how the splicing regulation of a gene modulates the gene’s function.