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Computational Biology |
InterAction Meeting Session, Bryn Mawr, Philadelphia, USA
Tuesday 14 October 2008
chaired by Debraj GuhaThakurta (Rosetta Inpharmatics, Merck & Co.) Bio....
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Biomedical research, be it in the biopharmaceutical industry, academia or governmental laboratories, is becoming an information driven science. An enormous amount of data is either present in published literature and patents or being generated using high-throughput technologies (such as DNA sequencing, microarrays, genome-wide association, proteomics etc.). The resulting computational biology challenges currently involve the development of intelligent data mining methodologies for these high-dimensional data and the development of databases that facilitate the hosting and integration of these diverse data-sets. The computational advances being made in these areas are significantly impacting biomedical research ranging from fundamental biological findings that relate genes and environment to disease all the way to molecular biomarkers for drug efficacy or toxicity. In this session, we have gathered a set of top speakers who have significant experience in the areas of data mining and integration. Presentation and discussion topics will include: molecular network reconstruction from genetically segregating populations (Paul McDonagh), the use of molecular networks for environmental risk assessment (Stephen Edwards), semantic web technologies for modeling biological pathways (Christopher Bouton), application of integrated genomics and genetics in pharmaceutical discovery (Debraj GuhaThakurta), and comparative genomics in drug discovery (James Brown).
Presenters & Discussions Leaders
Christopher M.L.S. Bouton (Blue Tree Consulting), Semantic Web Modeling of Biological Systems Abstract & Bio....
James R. Brown (GlaxoSmithKline), Comparative Genomics and Drug Discovery
Abstract & Bio....
Jake Chen (Indiana University), Translational Bioinformatics: Challenges for New Computational Tools
Abstract & Bio....
Stephen W. Edwards (U.S. Environmental Protection Agency), Systems Biology and Mode of Action Based Risk Assessment Abstract & Bio....
Debraj GuhaThakurta (Rosetta Inpharmatics, Merck & Co.), Using Genetics, Gene Expression and Pathway Mining in Pharmaceutical Discovery: Application towards Metabolic and Cardiovascular Disorders Abstract & Bio....
Paul McDonagh (Gene Network Sciences), Reverse Engineering and Simulating Causal Genetical Genomics Networks Abstract & Bio....
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