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Program and Schedule
| | InnovationWell InterAction Meeting at Bryn Mawr, Philadelphia (14-17 October 2008) |
MONDAY 13 OCTOBER
07.30 Registration & Welcome Coffee Opens, Thomas Great Hall, Bryn Mawr College
Pre-Conference Workshop: Advances in Information, Communications and Knowledge Management Support Systems in R&D, chaired by John Conway (Accelrys) and Frank Hollinger (FRESH Directions Consulting), 09.00 – 18.00 [Thomas 110 & Thomas Great Hall]
Speaker Presentations and User Perspectives will be used to seed discussions on current and future research needs in Knowledge Management in R&D support systems, which will be carried out using a wiki-supported Knowledge Cafe format.
Presenters & Discussion Leaders
Frank Brown (Accelrys), Data is only valuable if you can extract the information
Chris Culberson (Merck Research Laboratories), Title TBA
Barry Hardy (Douglas Connect), Knowledge-Oriented Collaboration in Virtual Organisation Structures
Tim McIntyre (GlaxoSmithKline), Workflow Application Enhances Productivity
Ralph T. Mosley (Pharmasset), Going Big to Small: What happens when you leave Big Pharma?
Chris Smith (Pfizer), Title TBA
More Information on Workshop....
18.30 Refreshments & Dinner [Wyndham Alumnae House]
TUESDAY 14 OCTOBER
Systems Biology, chaired by Keith Elliston (Genstruct), 09.00 – 13.00 [Thomas 110]
More Information on Session including Abstracts and Biographies....
Details of Program TBA
13.00 Lunch
Computational Biology, chaired by Debraj GuhaThakurta (Rosetta Inpharmatics, Merck & Co.), 14.00 – 18.30 [Thomas 110]
More Information on Session including Abstracts and Biographies....
14.00 Chair’s Introduction & Opening Remarks
14.15 Stephen W. Edwards (U.S. Environmental Protection Agency), Systems Biology and Mode of Action Based Risk Assessment
14.45 Paul McDonagh (Gene Network Sciences), Reverse Engineering and Simulating Causal Genetical Genomics Networks
15.15 Christopher M.L.S. Bouton (Pfizer), Semantic Web Modeling of Biological Systems
15.45 Coffee Break
16.15 James R. Brown (GlaxoSmithKline), Comparative Genomics and Drug Discovery
16.45 Debraj GuhaThakurta (Rosetta Inpharmatics, Merck & Co.), Using Genetics, Gene Expression and Pathway Mining in Pharmaceutical Discovery: Application towards Metabolic and Cardiovascular Disorders
17.15 Panel Discussion
18.30 Poster Session, Refreshments and Food [Thomas Great Hall]
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WEDNESDAY 15 OCTOBER
Knowledge Management in Translational Medicine, David Bousfield (Ganesha Associates), 08.30 – 18.00 [Thomas 110]
More Information on Session including Abstracts and Biographies....
08.30 Chair’s Introduction & Opening Remarks
08.45 Christopher M.L.S. Bouton (Pfizer Inc.), Title TBA
09.15 Speaker & Title TBA
09.45 John Wilbanks (Creative Commons), Breaking down Barriers to Collaboration - the Health Commons Initiative
10.15 Coffee Break
10.45 Barry Bunin (Collaborative Drug Discovery), Community-based Collaborative Drug Discovery for Neglected Infectious Diseases and Cancer
11.15 Michael Liebman (Strategic Medicine, Inc.), Knowledge Management Solutions for Breast Cancer Biomarkers
11.45 Jerry Wright (Johns Hopkins Medical Institutions), Extending the GeneGo Pathway Analysis Platform to Understand Cystic Fibrosis
12.15 Panel Discussion
13.00 Lunch
14.00 Anastasia Christianson (AstraZeneca), Translating Pre-clinical Data to Clinical Outcomes
14.30 James Golden (Science Applications International Corporation), Collecting and Aggregating Open Source Intelligence for Translational Medicine
15.00 John Speakman (National Cancer Institute), The Cancer Biomedical Informatics Grid (caBIG™): Re-engineering the Clinical Trials Enterprise
15.30 Coffee Break
16.00 William Hayes (Biogen Idec), bioPharma Problems that Semantic Web Technologies can solve now
16.30 Andrew McMurry (Harvard Medical School), Using Peer-to-peer Network Systems to obtain Tissue – the Achievements of the Shared Pathology Informatics Network (SPIN)
17.00 Eugene Clark (Partners Healthcare), Supporting Clinical Infrastructure and Processes with a Genetic Knowledge Repository
17.30 Panel Discussion
18.30 Poster Session, Refreshments and Food [Thomas Great Hall]
THURSDAY 16 OCTOBER
Applications of Metabolomics to Drug Discovery & Development, chaired by Bruce Kristal (Brigham and Women’s Hospital), 09.00 – 13.00 [[Thomas 110]
More Information on Session including Abstracts and Biographies....
09.00 Chair’s Introduction & Opening Remarks
09.15 Bruce Kristal (Brigham and Women’s Hospital), Diet-based Plasma Metabolomics: Biomarkers for Disease Risk?
09.45 John Newman (USDA), Targeted Metabolomics in Drug Discovery
10.15 Alvin Berger (Metabolon), Metabolomics to Advance Drug Discovery
10.45 Coffee Break
11.15 Mark Sanders (Thermo Fisher Scientific), Title TBA
11.45 Pierre Beauparlant (Gemin X Pharmaceuticals Inc.), Target Identification Permits Rationale Development of the Prodrug GMX1777 for the Treatment of Melanoma
12.15 Panel Discussion
13.00 Lunch
Predictive ADME, chaired by Anthony E. Klon (Pharmacopeia Drug Discovery), 14.00 – 18.00 [Thomas 110]
More Information on Session including Abstracts and Biographies....
14.00 Chair’s Introduction & Opening Remarks
14.15 Anton Hopfinger (University of New Mexico), Novel MI-QSAR Descriptors for Use in Modeling Membrane Transport Processes Such as Skin Penetration Enhancement
14.45 Heidi Einolf (Novartis), Predictions of Metabolic Drug Drug Interactions
15.15 Yojiro Sakiyama (Pfizer), Application of Machine Learning Tools for in silico ADME Screening
15.45 Coffee Break
16.15 Olga Obrezanova (BioFocus DPI), Automatic QSAR Modeling of Blood-Brain Barrier Penetration by Gaussian Processes Method
16.45 Anthony E. Klon (Pharmacopeia), Comparison of Machine Learning Algorithms to Predict ADME
17.15 Panel Discussion
18.30 Knowledge Café & Dinner on Collaboration Opportunities in Predictive ADME & Predictive Toxicology [Thomas Great Hall]
FRIDAY 17 OCTOBER
Predictive Toxicology, chaired by Artem Cherkasov (University of British Columbia), 08.45 – 16.00 [Thomas 110]
More Information on Session including Abstracts and Biographies....
08.45 Chair’s Introduction & Opening Remarks
09.00 Alex Tropsha (UNC), Predictive Chemical Toxicity Models using in vitro - in vivo Correlations enriched by Cheminformatics
09.30 Ann Richards (EPA), EPA DSSTox and ToxCast Project Updates: Generating New Data and Linkages in Support of Public Toxico-Cheminformatics Efforts
10.00 Barry Hardy (Douglas Connect), OpenTox
10.30 Coffee Break
11.00 Artem Cherkasov (University of British Columbia), The use of Conventional Drug Design Technologies for Identification of Potential Endocrine Disruptors interacting with Sex-hormone Binding Globulin in Zebra Fish
11.30 Weida Tong (FDA), The FDA’s Endocrine Disruptor Knowledge Base (EDKB)– Lessons Learned in QSAR Modeling and Applications
12.30 Lunch
13.30 Curt Breneman (RPI), A Hard Look at Predictive Modeling: How Much Data is Enough?
14.00 Andreas Maunz (Freiburg Center for Data Analysis and Modelling), New Lazar Developments and Data Mining Techniques for the Identification of Structural Alerts
14.30 Panel Discussion
16.00 Close of Program
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